Originally used to treat muscle atrophy and repair damage, the anabolic potential of IGF-DES has been overexploited. Philippou et al. pointed out in the journal *Cell Communications and Signaling* that its local muscle-building efficacy far exceeds that of natural IGF-1. However, controversy ensued: the World Anti-Doping Agency has added it to its prohibited list, banning it both in and out of competition. The General Administration of Sport's Anti-Doping Center has also warned that misuse of supplements containing this ingredient may lead to doping violations.https://www.fiercerawsource.com/peptides/premium-high-purity-peptides-igf-des.html
Currently, the long-term risks of IGF-DES use are not fully understood, and there is a lack of officially approved standards for human application. Experts warn that even if its targeted muscle-building effects are significant, misuse for non-medical purposes not only violates sports fairness but may also cause health risks such as endocrine disorders, and should be treated with caution.
